Whether you have a marketed MAb with annual production levels at the ton scale per year or you're producing drugs for early clinical trials, BioSMB technology will benefit your process.

In clinical applications, BioSMB systems provide the flexibility and rapid set-up necessary to adjust to changing titers without employing additional hardware, and will decrease your time to market by employing a disposable processing strategy. The highest cost of good item in most clinical manufacturing facilities is the cost of the chromatographic resin. BioSMB allows up to an 80% reduction in these costs. Over the course of annual operation of a multi-product clinical facility, the savings are significant.

BioSMB^™ systems are proven to:

• Reduce your operational footprint. BioSMB will use a smaller system, less media and less buffer to process the equivalent amount of material.
• Enable disposability with multiple smaller columns.
• Increased specific productivity 2-8X
• Use Protein A to its lifetime in one campaign enabling disposable flow path
• Create practical multi-product facilities with fully disposable flow path

Large-Scale Production

In larger scale applications, BioSMB systems decrease the traditional high capital cost of chromatographic media, packing skids and large stainless steel columns. BioSMB technology enables a smaller footprint, less support infrastructure and a scalable configuration. Cost effective production is especially critical at this scale and the BioSMB platform can provide substantial reduction in purification costs.