Disposable, Scalable,
Deployable

  

Vaccines

BioSMB systems provide readily deployable and disposable downstream purification solutions essential to meeting the high, and some time urgent, demand for vaccines around the globe. BioSMB technology with its disposable, flexible, and scalable components and ability to be combined with monoliths and membrane adsorbers will enable onsite purification anywhere in the world on short notice. BioSMB systems:

  • Enable portable, fully disposable processing trains in combination with single use bioreactors
  • Provides enough capacity for full production
  • Eliminate the need for separate equipment for pre- and post-inactivation via disposable flow paths

A recent study has demonstrated several advantages of BioSMB technology over a batch process in an ion exchange purification of a virus-like particle therapeutic for H1N1.

BioSMB™ IEX Study on Swine H1N1 VLP


Jiang H. Purification of H5N1 and H1N1 VLP-based vaccine. Presented at Single-Use
Applications for Biopharmaceutical Manufacturing; 2010 Jun 15; La Jolla, CA.

 Specific Productivity of BioSMB for Swine HiN1 is much higher than that of batch, while buffer consumption is 60% lower


Product purities and yields are similar